1VIC

Dissolving enzyme

Treatment Effect

Dissolving enzymes are primarily used to break down hyaluronic acid and typically begin working within hours to a few days after injection, gradually decomposing and facilitating the absorption of the injected hyaluronic acid. For most individuals, a single injection significantly reduces the filling effect of hyaluronic acid and alleviates issues such as swelling and hard nodules. Usually, one treatment session (a single injection) is sufficient for effective dissolution; however, if a large volume of hyaluronic acid was injected or it has a high degree of cross-linking, multiple injections may be required for complete dissolution.

Is this suitable for me?

Suitable for individuals dissatisfied with hyaluronic acid filler results, such as those experiencing overfilling, poor contour, nodules, or hard lumps. It is also recommended for those with allergies to hyaluronic acid or severe adverse reactions following injection. However, individuals allergic to hyaluronidase, pregnant or breastfeeding women, and patients with uncontrolled severe systemic diseases (such as heart disease, diabetes, etc.) should not use it.

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Select Equipment

Enzyme dissolution injections generally require only standard syringes, with the key being the appropriate syringe size to ensure accurate aspiration and injection of the enzyme. Syringes of 1ml to 2ml are typically used. The gauge and length of the needle should be selected based on the injection site and depth; for facial injections, thinner and shorter needles are generally chosen to minimize pain and tissue damage.

Select Brand

Select Equipment

Hyaluronidase injections typically require standard syringes, with the key being to choose an appropriate syringe size to ensure accurate aspiration and injection of the enzyme. Syringes of 1ml to 2ml are commonly used. The gauge and length of the needle should be selected based on the injection site and depth; for facial injections, thinner and shorter needles are generally preferred to minimize pain and tissue damage.

Price

Price

The price of hyaluronidase is influenced by multiple factors, with brand being a significant one. Imported brands typically range from $135 to $405 per unit, while domestic brands are priced between $45 and $135 per unit. Additionally, the injection dosage affects the total cost: if a larger amount of hyaluronic acid requires dissolution, the dosage of hyaluronidase increases, thereby raising the overall expense. Pricing standards also vary by region and medical facility; prices in first-tier cities and at high-end clinics tend to be higher.

Expected Outcome

Expected Results

After hyaluronidase injection, most individuals can observe that the area treated with hyaluronic acid filler gradually returns to a state close to before the injection, with swelling, nodules, and other abnormal conditions alleviating or disappearing. However, the dissolution effect may vary among individuals; some may experience faster dissolution with noticeable results, while in cases involving highly cross-linked hyaluronic acid or filler injected long ago that has formed a capsule, the dissolution process may be slower and may not achieve complete removal.

Combination Therapy

Combination Therapy

Hyaluronidase is typically effective on its own for dissolving hyaluronic acid, but in certain cases, it can be combined with other treatments. For instance, after dissolving hyaluronic acid, if depressions or other issues appear in the local skin, hyaluronic acid can be re-injected or autologous fat grafting can be performed once the hyaluronidase has taken effect, depending on the condition, to improve appearance. Additionally, if an inflammatory reaction occurs locally during the dissolution process, anti-inflammatory medications can be used in combination for treatment.

Adverse Effects and Complications

Side Effects and Complications

Common side effects include localized pain, swelling, and redness, which typically subside gradually within a few days after injection. A small number of individuals may experience allergic reactions, presenting as rashes, itching, or difficulty breathing; severe allergic reactions require prompt anti-allergy treatment. Additionally, improper injection techniques can lead to complications such as local tissue damage or infection, resulting in symptoms like fever or localized pus formation.

Beyond the previously mentioned side effects such as localized pain, swelling, redness, and allergic reactions, hyperpigmentation may also occur, likely due to abnormal melanin metabolism following inflammatory stimulation. This condition generally requires a prolonged period to gradually fade. Furthermore, excessive dissolution can cause local tissue depression, affecting appearance, and may necessitate subsequent corrective treatments.

Select Instrument

Select the Instrument

As previously mentioned, hyaluronidase injections primarily utilize syringes, so care must be taken to select ones with high quality and appropriate specifications. Reputable medical facilities typically employ sterile, single-use syringes that have undergone rigorous disinfection to prevent cross-infection. Additionally, some facilities may provide auxiliary equipment, such as topical anesthetic applicators for local anesthesia, to minimize pain during the injection process.

Project Contraindications

Project Contraindications

Individuals with hypersensitivity to hyaluronidase are absolutely contraindicated from its use; patients currently on anticoagulant therapy or with coagulation disorders may face an increased risk of bleeding if hyaluronidase is administered, requiring caution or adjustment of the treatment plan under medical supervision; pregnant and lactating women are not recommended to use hyaluronidase due to their unique physiological conditions to avoid potential adverse effects on the fetus or infant; individuals suffering from severe systemic diseases, such as uncontrolled hypertension, diabetes, or heart disease, may not tolerate hyaluronidase injections and are therefore unsuitable for this procedure.

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Contraindications

Individuals with a known allergy to hyaluronidase should absolutely avoid its use. Patients currently taking anticoagulants or those with coagulation disorders may face an increased risk of bleeding when using hyaluronidase; therefore, its use should be approached with caution, or the treatment plan should be adjusted under the guidance of a qualified physician. Women who are pregnant or breastfeeding are not advised to use hyaluronidase due to their unique physiological conditions, as it may adversely affect the fetus or infant. Additionally, individuals suffering from severe systemic diseases, such as uncontrolled hypertension, diabetes, or heart disease, may not tolerate hyaluronidase injections and are generally unsuitable for this procedure.

Side effects

Side Effects

In addition to the previously mentioned side effects such as localized pain, swelling, redness, and allergic reactions, localized hyperpigmentation may also occur, which is likely related to abnormal pigment metabolism in the skin following inflammatory stimulation. This condition typically requires a prolonged period to gradually fade. Furthermore, excessive dissolution can lead to localized tissue depression, affecting appearance, and may necessitate follow-up corrective treatments.

Self-Symptom Check

Self-Diagnosis of Symptoms

If you experience persistent local swelling, pain, hard nodules, or abnormal shaping after hyaluronic acid injection, it may indicate a filling issue. In such cases, observe changes in local skin color and temperature; redness and warmth may suggest an inflammatory response. However, self-diagnosis is only a preliminary assessment; final diagnosis and treatment plans require evaluation by a qualified medical professional.

Select treatment plan

Select Treatment Plan

The physician will develop a treatment plan tailored to the patient's specific condition. First, the amount of hyaluronic acid injected, the timing of injection, and the degree of cross-linking are evaluated to determine the dosage and method for administering hyaluronidase. For smaller treatment areas, multiple local injections may be employed; for larger areas or deeper tissues, a more cautious injection strategy may be required. Additionally, the physician will consider any underlying medical conditions and establish appropriate adjunctive therapies and post-procedure care protocols.